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  • microRNA Regulation in Health and Disease
    microRNA Regulation in Health and Disease

    MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models.

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  • Securities Regulation
    Securities Regulation

    This is the nation’s first and oldest casebook on securities regulation.This edition has been streamlined for easier use, but it continues to provide instructors and students with the full range of tools for the in-depth study of securities regulation.It has been revised and updated to take into account the following:Initial coin offerings and sales of other crypto-assetsChanges in the primary and secondary capital markets, including high frequency tradingCertain amendments to the public disclosure requirementsAmendments to the limited offering exemptionsThe ongoing debate around elements of Rule 10b–5Regulation Best InterestRecent Supreme Court cases, including their implications for certain civil litigation and the SEC’s continued reliance on administrative proceedings

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  • Co-Regulation Handbook
    Co-Regulation Handbook

     Do you know a child who struggles to get started with things or who resists trying something new? Maybe they argue or have trouble joining other kids in conversation and play. Do you hear yourself prompting your child again and again? Do you feel frustrated or stuck, and long for a better way - a more positive way - to engage your child while guiding them toward independence? This book was written for parents, caregivers, professionals and more - to guide you on how to move away from prompting and prodding kids - and toward authentic connections and competent roles. You'll learn how to create a positive learning environment for everyone, and feel empowered as you thoughtfully expand roles and responsibilities."In this book, Ms. Murphy explains co-regulation as a way of being with, doing together, and teaching children with learning challenges. Instead of the adult directing and prompting the child through endless steps of an activity, a common method that can quickly become frustrating for all involved, with a co-regulation approach, the adult sets up activities such that the child has a specific role, one in which they are competent, and through this role the child, from the start, successfully participates in the whole, meaningful activity, and--and perhaps most importantly--participates in harmony together with the adult. More learning comes through creating alterations to the child's role (e.g., swapping roles), or adding complexity to the role or to the activity itself. In this way adults expand children's competence through meaningful participation and from a place of harmonious interaction. Activities included as examples are as disparate as cooking, playing games, and playdates. As in her Declarative Language Handbook, Ms. Murphy presents complex material with clarity and compelling, illustrative examples. This book will be invaluable for parents as well as teachers, and therapists across disciplines."Karen Levine, Ph.D., PsychologistLecturer on Psychiatry , Harvard Medical School"When Declarative Language Handbook came out I recommended the book to my Facebook and YouTube followers, many of whom shared with me how grateful they were for recommending the book to them. I will be doing the same with Co-Regulation Handbook. The brilliance of Linda's writing is her ability to make concepts practical and she provides clear and concise directions regarding how to implement strategies. Linda's voice fills a tremendous need in the ADHD world, which for decades has ignored the incredibly important role language plays in building skills. Like Declarative Language Handbook, I consider this book a necessity for parents of kids with ADHD."Ryan Wexelblatt, LCSW, ADHD-CCSP (ADHD Dude)"This book is a beautifully written guide on how to form a deep, meaningful and impactful partnership with your child. This is important for any child, but when your child experiences the world differently this partnership is invaluable. I have watched my son (and myself!) grow in so many ways since we started practicing co-regulation, and I feel so much more equipped to help him navigate a world that can be confusing and scary to him. In this book Linda will walk you through the process of learning about co-regulation in an easy to read and fun way. This book is a MUST READ, the knowledge in these pages will help transform the child's experience and set the stage to learn and grow together in a positive and meaningful way."Charlie's Mom"Relationship is the key to unlocking true reciprocal communication, intrinsic motivation, and a strong sense of self. Linda Murphy's companion books, Declarative Language Handbook and Co-regulation Handbook, are clear, concise and communicate core principles of person-centered care I find foundational in my work."Sherri Miller MS, CCC-SLP, Founder of Communicating Potential LLC

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  • European Banking Regulation
    European Banking Regulation

    Since the financial crisis, the field of banking regulation has seen an unprecedented wave of regulatory reform throughout the world.In Europe, the focus is on the creation of a Eurozone Banking Union which consists of three major components: a single bank supervisory mechanism, a common bank crisis management and resolution system, and a uniform system of deposit insurance.Those efforts have been supported by rules on the corporate governance of banks, especially on executive compensation, by a structural reform of the financial derivatives market and through other regulatory acts.This regulatory tsunami raises a number of questions: Why do banks need special regulation besides their obvious systematic importance for the financial system?How effective will the European single bank supervisory mechanism be?Does the common bank crisis management and resolution system successfully tackle the moral hazard problem of running a bank that is 'too big to fall'?Do the new rules on executive compensation mitigate this problem?How much safer will deposits be after the reformed system of financial deposits, and what are the costs?

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  • Is this regulation pointless?

    Without knowing the specific regulation in question, it is difficult to determine if it is pointless. Regulations are typically put in place to protect public safety, ensure fair competition, or address a specific issue. It is important to consider the context and purpose of the regulation before determining if it is pointless. Consulting experts or conducting a cost-benefit analysis can help evaluate the effectiveness and necessity of the regulation.

  • What are fitness supplements?

    Fitness supplements are products designed to support athletic performance, muscle growth, and overall health and wellness. They often come in the form of pills, powders, or liquids and contain a variety of vitamins, minerals, amino acids, and other ingredients that are believed to enhance physical performance and recovery. While some fitness supplements can be beneficial when used correctly and in conjunction with a healthy diet and exercise routine, it is important to consult with a healthcare provider before adding any new supplements to your regimen.

  • Is a regulation legally binding?

    Yes, a regulation is legally binding. Regulations are rules or laws created by an authority, such as a government agency, that have the force of law. This means that individuals and organizations are required to comply with regulations, and failure to do so can result in legal consequences. Regulations are enforceable and have the same legal weight as statutes or laws passed by a legislative body.

  • How does thermal regulation work?

    Thermal regulation is the process by which the body maintains a stable internal temperature. When the body gets too hot, blood vessels near the skin dilate to release heat, and sweat glands produce sweat to cool the body as it evaporates. When the body gets too cold, blood vessels constrict to conserve heat, and muscles may shiver to generate warmth. The hypothalamus in the brain plays a key role in monitoring and regulating body temperature, sending signals to the body to adjust its temperature as needed.

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  • Modern Financial Regulation
    Modern Financial Regulation

    Modern Financial Regulation is a practical guide to the Financial Services Act 2012.This new legislation will bring about major structural and regulatory changes to financial services, including: * abolition of the Financial Services Authority which is to be replaced with the Financial Conduct Authority and the Prudential Regulation Authority; * introduction of light touch regulation to be replaced by far more robust regime of regulatory, civil injunctive and criminal enforcement; * a new consumer focussed investigative and prosecution authority that will regulate consumer markets * a focus on 'principles based' enforcement, which mirrors the approach to consumer law of the Consumer Protection from Unfair Trading Regulations The Financial Services Act 2012 amends and consolidates various statutory provisions, and dovetails with several discrete areas of financial regulation including money laundering, insider trading and cartel offences.This new guide explains how all these various strands interlock and how the new approaches are likely to work in practice.Modern Financial Regulation is essential reading for anyone who requires an understanding of the legal framework underpinning the financial services sector.

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  • Fintech Regulation In Practice : Navigate the Complexities and Opportunities of Regulation
    Fintech Regulation In Practice : Navigate the Complexities and Opportunities of Regulation

    Fintech Regulation in Practice provides a clear, hands-on guide to the practical considerations that fintechs, banks adopting fintech and other key players in the fintech ecosystem need to take into account when embedding regulation. This book looks at how regulation applies to a fintech at the various stages of its lifecycle and what it means for other partners in the fintech ecosystem that are crucial to its success.Addressing the key pitfalls, tensions and opportunities that come with fintech regulation, Fintech Regulation in Practice offers practical cases and tips to help professionals and organizations navigate its complexities.It also explores key issues such as financial and operational resilience, cybersecurity and fighting financial crime, anti-money laundering best practices, information security, privacy and the concept of embedded finance.It will be essential reading for risk and compliance professionals in financial services, business owners of regulated and unregulated fintechs, financial services firms delivering or partnering with fintech, fintech investors and other key stakeholders within the fintech ecosystem.

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  • Nutrition and Physiology of Fish and Shellfish : Feed Regulation, Metabolism, and Digestion
    Nutrition and Physiology of Fish and Shellfish : Feed Regulation, Metabolism, and Digestion

    Nutrition and Physiology of Fish and Shellfish: Feed Regulation, Metabolism and Digestion is a solid reference on the most recent advances and fundamental subjects in nutrient metabolism, intestinal transport and physiology of taste in fish.The book covers the known nutrient requirements and deficiency effects for different fish, along with information on the digestion and metabolism of nutrients and energy.It discusses nutrient sources and preparation of practical and research feeds and provides directions for conducting fish nutrition and feeding experiments.Other sections address current topics of interest to researchers and nutritionists in aquaculture research and the feed and allied industry. Nutrition and Physiology of Fish and Shellfish: Feed Regulation, Metabolism and Digestion is written by an international group of experts and contains fresh approaches of both classical and modern concepts of animal nutrition.All chapters clearly provide the essential literature related to the principles of fish nutrition and physiology that will be useful for academic researchers, those working professionally in aquaculture industries, and for graduate level students and researchers.

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  • Banking Law and Regulation
    Banking Law and Regulation

    Banking Law and Regulation is the ideal textbook to accompany a modern course at undergraduate and post-graduate levels.A truly contemporary textbook, it fully addresses the current landscape of banking law and regulation post the 2008 financial crisis.Coverage is expertly balanced between transactional, regulatory, and private law topics across UK banking law, as well as European and international law, ensuring that this book covers everything needed for a full understanding.Packed with features, including diagrams, questions, key takeaways, and key bibliographies, student learning is supported and consolidated. _ Digital formats and resourcesThis textbook is available for students and institutions to purchase in a variety of formats, and is supported by online resources The e-book offers a mobile experience and convenient access, along with functionality tools, navigation features, and links that offer extra learning support: www.oxfordtextbooks.co.uk/ebooksThe text is also supported by online resources, which include web links to enhance research and updates to the law.

    Price: 52.99 £ | Shipping*: 0.00 £
  • Can fitness supplements affect fertility?

    Yes, fitness supplements can affect fertility. Some supplements, such as anabolic steroids and high doses of certain vitamins, can disrupt hormone levels and potentially impact fertility in both men and women. It's important to consult with a healthcare professional before taking any fitness supplements, especially if you are trying to conceive. Additionally, maintaining a balanced diet and regular exercise routine is crucial for overall reproductive health.

  • Can someone who is a beginner in fitness please help me with nutrition, including supplements, etc.?

    Yes, as a beginner in fitness, it's important to focus on a balanced and nutritious diet that includes a variety of fruits, vegetables, lean proteins, whole grains, and healthy fats. It's also important to stay hydrated by drinking plenty of water throughout the day. As for supplements, it's best to consult with a healthcare professional or a registered dietitian to determine if you have any specific nutrient deficiencies that may require supplementation. In general, it's best to get nutrients from whole foods whenever possible, but some people may benefit from certain supplements such as vitamin D or omega-3 fatty acids.

  • What is enzyme inhibition and regulation?

    Enzyme inhibition is the process by which a molecule binds to an enzyme and decreases its activity. This can occur through competitive inhibition, where the inhibitor competes with the substrate for binding to the active site, or through non-competitive inhibition, where the inhibitor binds to a different site on the enzyme and changes its shape or function. Enzyme regulation refers to the control of enzyme activity within a cell or organism. This can occur through various mechanisms, including allosteric regulation, covalent modification, and feedback inhibition, to ensure that the enzymes are functioning at the appropriate levels to maintain cellular homeostasis.

  • What is the regulation in Germany?

    In Germany, regulations are established by the government at both the federal and state levels. These regulations cover a wide range of areas including environmental protection, labor laws, consumer rights, and data privacy. The goal of regulations in Germany is to ensure the safety and well-being of its citizens, protect the environment, and promote fair competition in the market. Compliance with regulations is mandatory, and violations can result in fines or other penalties.

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